The one natural remedy that has gained the most interest is the Epimedium plant species, commonly known as Horny Goat Weed extract in its commercial format. The Epimedium plant family contains within it a special active flavonoid known as 'icariin' of which has shown to be the most potent natural (non-enhanced) PDE-5 inhibitor discovered to date.

This natural PDE-5 inhibitor is not over-intensified as that of a prescription impotence drug, but instead it builds up in the body over time (weeks, months) gradually reviving and maintaining healthy blood flow to the body including the penis. Each Epimedium plant is extracted to a particular percentage of icariin content and the range normally varies from the less potent extracts at 10% icariin purity and reaches up to around 60% icariin purity, this being the most potent icariin extract available.

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The higher the icariin percentage the more effective the extract will be for its purpose of being a PDE-5 inhibitor and so it is quite often known for men who are perfectly fine (sexually speaking) to use a 10% icariin Epimedium extract for general sexual health and to maintain their current healthy sex life. The high purity icariin extracts I.e 50% to 60% are the favored purity of men who do actually suffer from blatant erectile dysfunction and low sex drive. These high purity extracts are unsurprisingly also used for increasing the endurance levels and stamina of performance athletes and endurance athletes, such as bodybuilders who wish to increase there natural nitric oxide levels to allow them to gain more stamina within their workouts.